Abstract
NMR and topochemical studies of irreversible HIV-1 protease inhibitors containing a cis-epoxide as amide isostere have been carried out to identify conformational preference of the inhibitors in solution. The inhibitors prefer to adopt extended conformations similar to the beta-strand in solution.
MeSH terms
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Crystallography, X-Ray
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Epoxy Compounds* / chemistry
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HIV Protease Inhibitors / chemical synthesis
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HIV Protease Inhibitors / chemistry*
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HIV-1*
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Models, Molecular
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Molecular Mimicry*
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Protein Conformation
Substances
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Epoxy Compounds
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HIV Protease Inhibitors